recentpopularlog in

cancer

« earlier   
Twitter
There's a lot of misinformation out there, so start here: is NOT a cure for .

It's irresponsible to cl…
cancer  CBD  from twitter_favs
4 days ago by kitoconnell
The Cancer Industry: Hype vs. Reality - Scientific American Blog Network
Cancer medicine generates enormous revenues but marginal benefits for patients
healthcare  cancer  hype  business 
9 days ago by PieroRivizzigno
Cancers | Free Full-Text | Sarcomatoid Dedifferentiation in Renal Cell Carcinoma: From Novel Molecular Insights to New Clinical Opportunities | HTML
Abstract: Sarcomatoid features in renal cell carcinoma (RCC) have long been associated with dismal prognosis and poor response to therapy, while biological mechanisms underpinning sarcomatoid dedifferentiation remained obscure. Several efforts have been conducted to break down the molecular profile of sarcomatoid RCC and investigate different targeted therapeutic approaches. Mutations enriched for in sarcomatoid RCC involve, notably, TP53, BAP1, cell cycle, and chromatin-remodeling genes. The immunological landscape of these tumors is also gradually being uncovered, showing frequent expression of programmed cell death ligand-1 (PD-L1) and high levels of tumor-infiltrating lymphocytes. These features may be major determinants for the activity of immune checkpoint inhibitors in this population, which has been confirmed by retrospective studies and subgroup analyses of large randomized phase 3 trials. Combinations based on PD-1/PD-L1 inhibition have demonstrated response rates and complete responses in >50% and >10% of patients in the first-line metastatic setting, respectively, with median overall survival exceeding two years. This remarkable improvement in outcomes effectively establishes immune checkpoint inhibitor combinations as a new standard of care in patients with sarcomatoid RCC. New research fields, including epigenetic regulations and tumor–microenvironment interactions, may further sharpen understanding of sarcomatoid RCC and advance therapeutic developments.
RCC  cancer  Science 
10 days ago by cnk
Twitter
This is the reality .. sadly. I’m excited about the work of and a few others on as a…
cancer  from twitter
11 days ago by rickc57

Copy this bookmark:





to read