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Balance of two enzymes linked to pancreatic cancer survival
What's more, that ratio -- high PHLPP1/low PKC -- correlated with poor prognoses: no pancreatic patient with low PKC in the database survived longer than five-and-a-half years. On the flip side, 50 percent of the patients with low PHLPP1/high PKC survived longer than that.
science  cancer  pancreas 
15 hours ago by emkay
Drinking hot tea linked with elevated risk of esophageal cancer
Compared with drinking less than 700 ml of tea per day at less than 60°C, drinking 700 ml per day or more at a higher temperature (60°C or higher) was associated with a 90 percent higher risk of esophageal cancer.
science  cancer  tea 
18 hours ago by emkay
Epigenetic drivers of tumourigenesis and cancer metastasis - ScienceDirect
Since the completion of the first human genome sequence and the advent of next generation sequencing technologies, remarkable progress has been made in understanding the genetic basis of cancer. These studies have mainly defined genetic changes as either causal, providing a selective advantage to the cancer cell (a driver mutation) or consequential with no selective advantage (not directly causal, a passenger mutation). A vast unresolved question is how a primary cancer cell becomes metastatic and what are the molecular events that underpin this process. However, extensive sequencing efforts indicate that mutation may not be a causal factor for primary to metastatic transition. On the other hand, epigenetic changes are dynamic in nature and therefore potentially play an important role in determining metastatic phenotypes and this area of research is just starting to be appreciated. Unlike genetic studies, current limitations in studying epigenetic events in cancer metastasis include a lack of conceptual understanding and an analytical framework for identifying putative driver and passenger epigenetic changes. In this review, we discuss the key concepts involved in understanding the role of epigenetic alterations in the metastatic cascade. We particularly focus on driver epigenetic events, and we describe analytical approaches and biological frameworks for distinguishing between “epi-driver” and “epi-passenger” events in metastasis. Finally, we suggest potential directions for future research in this important area of cancer research.
epigenetics  Review  Cancer 
yesterday by Segalllab
Oral Cancer Foundation Run/Walk - March 30, 2019
We are extremely proud to join the effort of thousands of others to raise awareness for the Oral Cancer Foundation. Orsatti Dental in San Antonio, TX.
San  Antonio  Oral  Cancer  Foundation  Run 
yesterday by LocalBusiness

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