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mindfulness  kippt_pricey_or_paid_mindfulness_apps  kippt_pricey_or_paid_mental_health_apps  kippt_mental_health_apps  mental_health  SaaS  iOS_apps  android_apps  yearly  paid  trial  price:$55  recommended_by_FM 
3 days ago by skinnymuch
The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial | Annals of Internal Medicine | American College of Physicians
Fifty-three percent of participants (n = 1711) had the metabolic syndrome at baseline; incidence did not vary substantially by age. However, low levels of high-density lipoprotein cholesterol predominated in younger participants (age 25 to 44 years), and high blood pressure predominated in older participants (age 60 to 82 years). In life-table analyses (log-rank test), incidence of the metabolic syndrome was reduced by 41% in the lifestyle group (P < 0.001) and by 17% in the metformin group (P = 0.03) compared with placebo. Three-year cumulative incidences were 51%, 45%, and 34% in the placebo, metformin, and lifestyle groups, respectively. There was no significant heterogeneity by ethnic group.

The study involved a volunteer group with impaired glucose tolerance, which limits generalizability.

The metabolic syndrome affected approximately half of the participants in the Diabetes Prevention Program at baseline. Both lifestyle intervention and metformin therapy reduced the development of the syndrome in the remaining participants.
metabolic  syndrome  treatment  intervention  behavioral  diet  dietary  drug  comparison  metformin  peer-reviewed  research  in  vivo  human  clinical  trial 
14 days ago by Michael.Massing
Low-glycemic index diets as an intervention for diabetes: a systematic review and meta-analysis. - PubMed - NCBI
We searched PubMed, the Cochrane Library, EMBASE, and clinical trials registries for published and unpublished studies up until 1 March, 2019. We included 54 randomized controlled trials in adults or children with impaired glucose tolerance, type 1 diabetes, or type 2 diabetes. Continuous data were synthesized using a random effects, inverse variance model, and presented as standardized mean differences with 95% CIs.

Low-GI diets were effective at reducing glycated hemoglobin (HbA1c), fasting glucose, BMI, total cholesterol, and LDL, but had no effect on fasting insulin, HOMA-IR, HDL, triglycerides, or insulin requirements. The reduction in fasting glucose and HbA1c was inversely correlated with body weight. The greatest reduction in fasting blood glucose was seen in the studies of the longest duration.

Low-GI diets may be useful for glycemic control and may reduce body weight in people with prediabetes or diabetes.
foods  low  GI  glycemic  index  diet  food  weight  loss  maintenance  body  fat  clinical  trial  meta-analysis  RCT  peer-reviewed  research  human  in  vivo  systematic  review  HbA1c  biomarkers  treatment  improvement  intervention  fasting  glucose  BMI  total  cholesterol  LDL 
14 days ago by Michael.Massing
Comparison of High-Fiber and AHA Diets | Annals of Internal Medicine | American College of Physicians
At 12 months, mean change in weight was −2.1 kg (95% CI, −2.9 to −1.3 kg) in the high-fiber diet group versus −2.7 kg (CI, −3.5 to −2.0 kg) in the AHA diet group. The mean between-group difference was 0.6 kg (CI, −0.5 to 1.7 kg). During the trial, 12 (9.9%) and 15 (12.6%) participants dropped out of the high-fiber and AHA diet groups, respectively (P = 0.55). Eight participants developed diabetes (hemoglobin A1c level ≥6.5%) during the trial: 7 in the high-fiber diet group and 1 in the AHA diet group (P = 0.066).

Generalizability is unknown. Maintenance of weight loss after cessation of group sessions at 12 months was not assessed. Definitive conclusions cannot be made about dietary equivalence because the study was powered for superiority.

The more complex AHA diet may result in up to 1.7 kg more weight loss; however, a simplified approach to weight reduction emphasizing only increased fiber intake may be a reasonable alternative for persons with difficulty adhering to more complicated diet regimens.
fat  loss  weight  maintenance  body  fiber  diet  food  treatment  intervention  clinical  trial  human  in  vivo  research  peer-reviewed  comparison 
14 days ago by Michael.Massing
Beepify – Simply the Best MacBook Theft Protection Ever Invented
Sends you a notifications. An "alarm" goes off if cable is disconnected or screen is closed.

7 day trial then $15/yr or $1.25/mo.
interesting  mac_apps  paid  setapp  unique_spin_slightly  SaaS  yearly  trial 
16 days ago by skinnymuch
The Effect of Diet and Exercise or Metformin on the Metabolic Syndrome | Annals of Internal Medicine | American College of Physicians
Over half of the patients had the metabolic syndrome at the start of the study. Diet and exercise or metformin each prevented the development of the metabolic syndrome in patients who did not have it at the start of the study. Patients who had the syndrome at the start of the study were more likely to be free of it at the end if they received a diet and exercise intervention or metformin than if they received neither. The benefit of the diet and exercise program was larger than the benefit of metformin.

What were the limitations of the study?

The study included only people with impaired glucose tolerance, so it might not apply to people with normal blood sugar. The study was also too short to see whether the reduction in the metabolic syndrome led to fewer cardiovascular events.

What are the implications of the study?

Diet and exercise or metformin can reduce the metabolic syndrome in people with high blood sugar.
metformin  treatment  self  drug  behavioral  exercise  diet  clinical  trial  metabolic  syndrome  care  improvement  prevention  symptom  comparison  peer-reviewed  research  impaired  glucose  tolerance  dysglycemia  hyperglycemia 
18 days ago by Michael.Massing
Elektra Labs
Accelerate your clinical trial.
Request a custom report using our catalog of 600+ wearables and remote sensors. via sageassembly Andrea Coravos
clinicaltrial  clinical  trial  study 
4 weeks ago by sprague
FruitJuice -- battery maintenance app for Apple Mac laptop computers. —
FruitJuice helps you keep your Apple Mac Laptop battery running and lasting longer.
mac_apps  %i_legit_use_this  paid  K  battery_related  utilities  trial 
6 weeks ago by skinnymuch
Theranos founder Elizabeth Holmes’ fraud trial may not start until September 2020 • Silicon Valley
Ethan Baron:
<p>Lawyers and prosecutors in the federal criminal case against disgraced Theranos founder Elizabeth Holmes have agreed on a September 2020 start date for a trial expected to take three months, according to a new court filing.

Holmes is charged with felony conspiracy and fraud for allegedly misleading patients, doctors and investors about her now-defunct Silicon Valley blood-testing startup. She and former company president Sunny Balwani were indicted by a grand jury in June. They are charged with 11 criminal counts of wire fraud and conspiracy to commit wire fraud.

On Friday, federal prosecutors and lawyers for Holmes and Balwani filed a joint memo in San Jose U.S. District Court, saying the prosecution did not oppose the proposal by lawyers for Holmes and Balwani to start the trial in September 2020, “or as soon thereafter as would be convenient for the court.” Prosecutors had preferred a start date in the first half of 2020, but the defense maintained that more time was needed to prepare, according to the memo.</p>

So it will suck up huge amounts of time and money and happen much later than we'd hoped, if at all. Somehow this seems fitting.
theranos  trial 
8 weeks ago by charlesarthur

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