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Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila: Cell Reports
In summary, we propose a model whereby the activity of WASp-Arp2/3 generally increases the efficiency of endocytosis and becomes specifically required only during cytokinesis, when Dl activates Notch to mediate intra-lineage decisions. This model may be general and apply to mammalian tissues where Notch is known to regulate intra-lineage decisions (Dong et al., 2012
, Pardo-Saganta et al., 2015
). N-WASp, the ubiquitously expressed WASp in mammals, is required for the maintenance of skin progenitor cells and hair follicle cycling in the mouse (Lyubimova et al., 2010
), and Notch plays a critical role in the self-renewal of skin stem cells (Blanpain et al., 2006
, Martincorena et al., 2015
). Whether Notch signaling is regulated by N-WASp in this context remains to be examined.
Notch  endocytosis  wasp  arp2/3  asymmetric_division  delta_ligands 
11 weeks ago by Segalllab
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Turns out it has been this and the incredibly long thing I saw wasn't it's body, but dry grass stalks it must…
wasp  from twitter_favs
12 weeks ago by tikitu
WIP/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions - ScienceDirect
Could these be TNTs?

WIP (WASP interacting protein) together with N-WASP (neural Wiskott-Aldrich syndrome protein) regulates actin polymerization that is crucial for invadopodia and filopodia formation. Recently, we reported the WIP interaction with ITSN1 which is highly implicated in endo-/exocytosis, apoptosis, mitogenic signaling and cytoskeleton rearrangements. Here we demonstrate that the WIP/ITSN1 complex is involved in the transferrin receptor recycling and partially co-localizes with a marker of the fast recycling endosomes, RAB4. Moreover, ITSN1 recruits WIP to RAB4-positive vesicles upon overexpression. Our data indicate that WIP enhances the interaction of N-WASP with ITSN1 and promotes ITSN1/β-actin association. Moreover, the WIP/ITSN1-L complex facilitates formation of filopodia-like protrusions in MCF-7 cells. Thus, WIP/ITSN1 complex is involved in the cellular vesicle trafficking and actin-dependent membrane processes.
TNTs  NWasp  wasp  wip 
february 2019 by Segalllab
WASP 3d printed house
Crane WASP The Infinity 3d printer is a modular collaborative 3D printing system. It reinterprets the classic building cranes from a digital manufacturing point of view. It is composed of a main printer unit that can be assembled in different configurations depending on the printing area and therefore on the dimensions of the architectural structure to be calculated in 3d.
3dprinting  architecture  house  construction  wasp 
october 2018 by cyberchucktx

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