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A Cancer Patient’s Guide to Clinical Trials — ProPublica
If you’re considering whether to enroll in a trial of an experimental drug, here’s what you need to know.
healthcare  trial  patient 
6 days ago
The market trend analysis and prospects of cancer molecular diagnostics kits | Biomaterials Research | Full Text
The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnostic technique. Also, depending on the disease being diagnosed, the market can also be divided into cancer, infectious diseases, HIV/STDs (herpes, syphilis), and women’s health issues such as breast cancer, cervical cancer, ovarian cancer, HPV(human papillomavirus), and vaginitis.
healthcare  molecular-diagnostic  market-size 
21 days ago
What Spotify's DNA-Test Playlist Gets Wrong About Genetic Ancestry - The Atlantic
A Spotify playlist tailored to your DNA is the latest example of brands cashing in on people’s search for identity.
coupling  genetics  DNA  Spotify  counterpoint 
21 days ago
Frontiers | The Potential of CAR T Cell Therapy in Pancreatic Cancer | Immunology
This review summarizes the available preclinical data and highlights early phase clinical trials using CAR T cell approaches in pancreatic cancer, a disease state that is gaining attention as a conduit for cell therapy. Future directions in application of CAR T cell therapy are also considered including its ability to be directed against novel epitopes and combined with other therapeutic regimens.
healthcare  cancer  pancreas  CAR-T  immunotherapy 
23 days ago
A Run of Contrary Results | In the Pipeline
From the outside, medical progress looks a lot easier than it really is. Well, I realize that’s true of a lot of things, but it’s especially true in progress against disease, and that’s especially especially true (as I’ve said here before) when you’re talking about dietary influences and what can be learned from them. Butter, whole milk, and other dairy products – bad for your cardiovascular health, right? Not according to this new observational study of 136,000 people across 21 countries.
healthcare  nutrition  counterpoint 
23 days ago
(38) Pancreatic Cancer: Advances in Science and Clinical Care - YouTube
This AACR Special Conference, to be held September 21-24, 2018, in Boston, will convene world-renowned experts covering the breadth of research on pancreatic cancer, from early detection and genetics to precision medicine and immunotherapy.
healthcare  cancer  pancreas  AACR  state-of-art 
23 days ago
21st Century Physician: Triaging the Tsunami of Medical Information
I am occasionally asked for advice on keeping up with the tsunami of medical information while separating facts from spin. Here are my tips.
healthcare  how-to-read 
23 days ago
Genetic determinism rides again
And yet, here we are again with Blueprint, by educational psychologist Robert Plomin. Although Plomin frequently uses more civil, progressive language than did his predecessors, the book’s message is vintage genetic determinism: “DNA isn’t all that matters but it matters more than everything else put together”. “Nice parents have nice children because they are all nice genetically.” And it’s not just any nucleic acid that matters; it is human chromosomal DNA. Sorry, microbiologists, epigeneticists, RNA experts, developmental biologists: you’re not part of Plomin’s picture.
healthcare  genetics  determinism  reductionism 
24 days ago
How one pharmaceutical company is reinventing the clinical trial - STAT
Clinical trials are as essential today as drug discovery for bringing new drugs to market. But while new tools and technologies have helped advance techniques for new drug discovery, we’ve seen far less innovation in clinical trials. The process continues to be weighed down with regulatory paperwork, medical jargon, and participants’ time-intensive trips to trial sites.
healthcare  clinical-trial  trial  Jansen  Scripps  digital-health 
28 days ago
Sloan Kettering’s Cozy Deal With Start-Up Ignites a New Uproar - The New York Times
The company, Paige.AI, is one in a burgeoning field of start-ups that are applying artificial intelligence to health care, yet it has an advantage over many competitors: The company has an exclusive deal to use the cancer center’s vast archive of 25 million patient tissue slides, along with decades of work by its world-renowned pathologists.
healthcare  pathology  Memorial-Sloan-Kettering-Cabcer-Center  cancer  conflict-of-interest 
28 days ago
Everyday Sociology Blog: A Sociology of My Death
I’m dying. I don’t mean this figuratively—like I’m dying of thirst or dying to visit Hawaii. I mean it quite literally. I have incurable, stage IV lung cancer.
healthcare  sociology  death 
4 weeks ago
Cancer treatment in the last 6 months of life: when inaction can outperform action. ecancermedicalscience - The open access journal from the European Institute of Oncology and the OCEI
For example, when a patient’s life expectancy is less than 6 months, many oncologists will not embark on any active cancer treatments. However, multiple new anticancer drugs have been approved recently after being tested in end-stage cancer patients and demonstrating median OS in the experimental arm close to 6 months. Such practice, particularly when the treatment is also accompanied by serious toxicities and cost, can undermine a peaceful life-death transition.
cancer  ethics  healthcare  end-of-life 
4 weeks ago
UX Guidelines for Ecommerce Homepages, Category Pages, and Product Listing Pages
Streamline users’ path to products by providing clear, differentiating product information at all levels — from the homepage to product listing pages.
Design  Guidelines  E-commerce  UX 
4 weeks ago
Designing notifications for apps – Muzli - Design Inspiration
Explore different notification models and when to use which
notification  Design 
4 weeks ago
Designing a food delivery app for motorbike drivers — a UX case study
The following case study is part of a design challenge. I am not in any way affiliated to Grab or any other companies/individuals mentioned in this article. The design decisions and assumptions taken in this case study are solely based on publicly available information
app  food-delivery  Design 
4 weeks ago
Amazon’s Antitrust Antagonist Has a Breakthrough Idea - The New York Times
With a single scholarly article, Lina Khan, 29, has reframed decades of monopoly law.
monopoly  digital-economy  Amazon  antitrust  law 
4 weeks ago
TechCrunch - Disrupt SF 2018 | Anne Wojcicki (23andMe) | Facebook
23andMe CEO Anne Wojcicki on the tremendous opportunities that can be unlocked by genetic testing
healthcare  cancer  precision-medicine  23andme  interview  video 
5 weeks ago
(30) Understanding Nutrition and the Role and Benefits of PERT - YouTube
This animation describes pancreatic enzyme replacement therapy (PERT) and it’s role and benefit for patients who have exocrine pancreatic insufficiency (EPI). The animation provides an overview of the role of pancreatic enzymes in food digestion, the different types of PERT medications that are currently available, and provides tips for dosing and timing of PERT. For the majority of patients taking PERT, there is a significant improvement of symptoms, nutritional status, and overall quality of life.
Visit to learn more.
healthcare  cancer  pancreas  nutrition  enzymes 
5 weeks ago
OncoKB: A Precision Oncology Knowledge Base | JCO Precision Oncology
With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, an urgent need exists for a clinical support tool that distills the clinical implications associated with specific mutation events into a standardized and easily interpretable format. To this end, we developed OncoKB, an expert-guided precision oncology knowledge base.
healthcare  cancer  precision-medicine  OncoKB  SMKC 
5 weeks ago
The four ways that ex-internet idealists explain where it all went wrong - MIT Technology Review
21st-century digital evangelists had a lot in common with early Christians and Russian revolutionaries.
digital-culture  Internet  evangelist 
5 weeks ago
Neuroendocrine Cancer and Pancreatic Enzyme Replacement Therapy (PERT) – the Digested Version (Nutrition Series Article 5) – Ronny Allan – Living with Neuroendocrine Cancer
We eat food, but our digestive system doesn’t absorb food, it absorbs nutrients. Food has to be broken down from things like steak and broccoli into its nutrient pieces: amino acids (from proteins), fatty acids and cholesterol (from fats), and simple sugars (from carbohydrates), as well as vitamins, minerals, and a variety of other plant and animal compounds. Digestive enzymes, primarily produced in the pancreas and small intestine, break down our food into nutrients so that our bodies can absorb them.
healthcare  cancer  pancreas  nutrition  enzymes  Allan  reference 
5 weeks ago
Palliative Care in Metastatic Pancreatic Cancer
Panelists: John L. Marshall, MD, Georgetown University; George Kim, MD, 21st Century Oncology; Kabir Mody, MD, Mayo Clinic Cancer Center; Eileen M. O
Published: Monday, Aug 27, 2018
healthcare  cancer  pancreas  palliative  care 
5 weeks ago
Patient Checklist - Lustgarten Foundation: Pancreatic Cancer Research
As overwhelming as a pancreatic cancer diagnosis is, it is important to act quickly and put a treatment plan into place. Treatment should ideally begin within one month after you receive your diagnosis.
healthcare  cancer  pancreas  checklist  Lustgarten 
5 weeks ago
All study participants have a right to know their own results- STAT
Between the rise in direct-to-consumer products and more transparent medical care, people today have access to myriad types of data about their personal health — and they’ve come to expect it. Yet for participants in most research studies, outdated ethical standards prevent them from learning anything at all about what was found in their blood, urine, or any other tissue they donated for research.
healthcare  trial  data  patient  transparency 
5 weeks ago
Estimation of the Acquisition and Operating Costs for Robotic Surgery | Minimally Invasive Surgery | JAMA | JAMA Network
Despite evidence questioning the clinical benefit,1 the use of the robotic platform for surgical procedures is increasing.2 No benchmark exists for the cost of acquiring and operating robotic systems, and previous cost evaluations have either omitted key expenses1 or utilized billing records that do not itemize costs with sufficient granularity.2
healthcare  surgery  robotics  cost 
5 weeks ago
Dynamic Behavior of Ca 19-9 and Pancreatic Cancer Recurrence: Enough Data to Drive Salvage Therapy? | SpringerLink
Up to 80% of patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma (PDAC) followed by adjuvant therapy will recur within 2 years, with median recurrence-free survival (RFS) of only 1 year.1
healthcare  cancer  pancreas  surgery  CA-19.9  Verona 
5 weeks ago
Design Thinking Is Fundamentally Conservative and Preserves the Status Quo
When it comes to design thinking, the bloom is off the rose. Billed as a set of tools for innovation, design thinking has been enthusiastically and, to some extent, uncritically adopted by firms and universities alike as an approach for the development of innovative solutions to complex problems.  But skepticism about design thinking has now begun to seep out onto the pages of business magazines and educational publications.
Design-Thinking  counterpoint 
5 weeks ago
The paradox of precision medicine | Nature Reviews Clinical Oncology
According to the paradigm of precision medicine, the administration of agents targeting the molecular alteration detected in a particular patient’s tumour reduces uncertainty in the clinical management of that patient. We describe how approaches to precision medicine can lead, paradoxically, to increased levels of uncertainty. We offer recommendations for how physicians can better navigate new uncertainties in precision medicine.
healthcare  cancer  precision-medicine  counterpoint 
5 weeks ago
Opinion | Are We Being Misled About Precision Medicine? - The New York Times
Doctors and hospitals love to talk about the cancer patients they’ve saved, and reporters love to write about them. But deaths still vastly outnumber the rare successes.
healthcare  cancer  precision-medicine  counterpoint 
5 weeks ago
Addressing Financial Barriers to Patient Participation in Clinical Trials: ASCO Policy Statement: Journal of Clinical Oncology: Vol 0, No 0
Research conducted through clinical trials is essential for evaluating new treatment modalities, establishing new standards of cancer care, and ultimately improving and prolonging the lives of patients with cancer. However, participation in trials has been low, and this is attributable to various factors including patient financial barriers.
healthcare  trial  patient  participation  barriers  financial 
5 weeks ago
Inevitability in technology — Benedict Evans
The statesman's task is to hear God's footsteps marching through history and to try and catch on to his coattails as he marches past'
8 weeks ago
New Strategies for Securing Our Private Lives - Lawfare
I recently wrote an essay reflecting on the reality that nearly anyone with a life online is today subject to being hacked and having anything private become public
privacy  zittrain 
8 weeks ago
Need a paper? Get a plug-in
A collection of web-browser plug-ins is making the scholarly literature more discoverable.
Unpaywall  Book  science  plug-in  free 
8 weeks ago
How Unpaywall is transforming open science
Unpaywall has become indispensable to many academics, and tie-ins with established scientific search engines could broaden its reach.
open-source  Book  free-availability  Unpaywall  science 
8 weeks ago
Utilizing Patient-reported Outcomes in Cancer Clinical Trials - CANCER RESEARCH Catalyst
Assessing new anticancer therapeutics in clinical trials is a vital step in evaluating the toxicity and efficacy of treatments before their approval for widespread use. Throughout these trials, many patients encounter a variety of side effects, ranging from physical ailments such as nausea or rash to psychological symptoms such as depression or anxiety. While it is standard practice to record clinician-reported outcomes to characterize safety, there is no current standard requirement for the use of patient-reported outcomes (PROs) in cancer clinical trials.
digital-health  PRO 
8 weeks ago
Identification of performance indicators across a network of clinical cancer programs
Cancer quality indicators have previously been described for a single tumour site or a single treatment modality, or according to distinct data sources. Our objective was to identify cancer quality indicators across all treatment modalities specific to breast, prostate, colorectal, and lung cancer.
healthcare  cancer  kpi  center 
8 weeks ago
WuXi NextCODE: A Contract Genomics Organization
Built over twenty years on the world’s largest collection of human genomes, our platform today powers the biggest and most innovative precision medicine efforts on four continents, including pioneering population-optimized genome tests and wellness products in China.
healthcare  digital-health  Platform  genomics 
9 weeks ago
Providing help and guidance to applicants
Building on that work, our design team reimagined the end-to-end help experience, and established help content design patterns for the entire site. The primary goal: to respectfully and clearly guide people through what can oftentimes be a deeply personal process, one that will determine how they care for themselves and their family.
healthcare  Design  applications 
9 weeks ago
The Future Of Clinical Trials: The Promise Of AI And The Role Of Big Tech
Testing new drugs is a slow, expensive, and manual process. Artificial intelligence has the potential to disrupt every stage of the clinical trials process — from matching eligible patients to studies to monitoring adherence and data collection.
clinical-trial  digital-health  AI 
9 weeks ago
37 Startups building voice applications for healthcare | MobiHealthNews
next frontier in human-technology interfaces, voice-enabled and voice-first technologies are leading the way in many innovative applications across industries. Predictions that 50 percent of searches will be voice-based by 2020 and that 55 percent of US households will have a smart speaker by 2022 have entrepreneurs, developers, product managers, and marketers rushing to figure out how they can capture the upcoming surge of voice-based technology.
digital-health  Startup  voice-enabled 
9 weeks ago
A guide to using the Theoretical Domains Framework of behaviour change to investigate implementation problems | Implementation Science | Full Text
Implementing new practices requires changes in the behaviour of relevant actors, and this is facilitated by understanding of the determinants of current and desired behaviours. The Theoretical Domains Framework (TDF) was developed by a collaboration of behavioural scientists and implementation researchers who identified theories relevant to implementation and grouped constructs from these theories into domains
healthcare  TDF  new-practices 
10 weeks ago
Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis. - PubMed - NCBI
Periodontal disease (PD), now our commonest infectious disorder leads to tooth loss, and has been linked to various systemic diseases, including various types of cancer. The aim of this study is to provide a systematic review and a meta-analysis of the relationship between PD, edentulism, and pancreatic cancer (PC).
healthcare  cancer  pancreas  periodontal-disease 
11 weeks ago
The Most Powerful Doctor You Never Heard Of
The new law even creates a Patient-Centered Outcomes Research Institute that aims to extend the type of work Krumholz does in cardiology to other medical arenas such as cancer and psychiatry.
healthcare  PRO 
11 weeks ago
What Can Odd, Interesting Medical Case Studies Teach Us? - The New York Times
These days, we typically write observational reports on single patients to teach students about the past: This is how this medical mystery was cracked. But perhaps we might revive the case study that looks to the future: I cannot diagnose this condition, or explain it away, but I will record it in its fullest, richest form for another generation of medical students to puzzle over.
healthcare  medical-case  report  mystery 
11 weeks ago
Applying systems thinking in product design - Inside Intercom
“A system is an interconnected set of elements that is coherently organized in a way that achieves something.”
DPD  Design  system-thinking 
july 2018
Product Managers Are Obsolete; Focus on the Job-to-be-Done - Strategyn
While the role of the product manager is critical, we feel that the title “product manager” is a legacy of outdated business thinking. We therefore advocate doing away with the traditional product manager and propose a new title and responsibility
Product-Manager  DPD  counterpoint 
july 2018
Product managers for the digital world | McKinsey & Company
The role of the product manager is expanding due to the growing importance of data in decision making, an increased customer and design focus, and the evolution of software-development methodologies.
Product-Manager  DPD 
july 2018
Dr. O'Reilly on Immunotherapy in Pancreatic Cancer
Eileen O'Reilly, MD, associate director for clinical research at Memorial Sloan Kettering Cancer Center, discusses the role of immunotherapy in the treatment of patients with pancreatic cancer.
healthcare  cancer  pancreas  immunotherapy  O'Reilly-E  video 
july 2018
The Online Gene Test Finds a Dangerous Mutation. It May Well Be Wrong. - The New York Times
Third-party analysis of raw DNA is not as rigorous as that done in a certified laboratory. But many consumers don’t understand that their results are not conclusive.
healthcare  genomics-testing  counterpoint 
july 2018
What Patients Look for When Browsing Online for Pancreatic Cancer: The Bait Behind the Byte | SpringerLink
Suitability is a patient-centered metric defined as how appropriately health information is targeted to specific populations to increase knowledge. However, suitability is most commonly evaluated exclusively by healthcare professionals without collaboration from intended audiences. Suitability (as rated by intended audiences), accuracy and readability have not been evaluated on websites discussing pancreatic cancer.
healthcare  cancer  pancreas  online-info  digital 
july 2018
Definition of Digital Health - Paul Sonnier
Digital health is the convergence of the Digital and Genomic Revolutions with health, healthcare, living, and society.
digital-health  definition 
july 2018
Identifying How Patient Portals Impact Communication in Oncology: Health Communication: Vol 0, No 0
Patient portals are becoming widespread throughout health-care systems. Initial research has demonstrated that they positively impact patient–provider communication and patients’ health knowledge, but little is known about the impact of patient portals in the cancer setting, where highly complex and uncertain medical data are available for patients to view. To better understand communicative behaviors and perceptions of the patient portal and how it is utilized in oncology
healthcare  cancer  oncology  patient-communication  patient-portal 
july 2018
Algorithms in Culture: Big Data & Society: SAGE Journals
A foundational concept in computer science, algorithms – loosely defined as a set of rules to direct the behavior of machines or humans - have shaped infrastructures, practices, and daily lives around the world. This special theme, based on a December 2016 conference at University of California at Berkeley, considers algorithms as objects of cultural inquiry. It explores the implications of their development and deployment across many Big Data contexts, including politics, journalism, criminal justice, science, organizations, labor, culture, and the construction of the self.
algorithm  culture  digital-culture  Bigdata  data-society  counterpoint 
july 2018
FDA Regulation of Mobile Medical Apps | Regulatory Agencies | JAMA | JAMA Network
Mobile apps are increasingly used in health care to promote wellness, treat and diagnose disease, aid clinical decision-making, and manage patient care in hospitals and homes
FDA  digital-health 
july 2018
Analysis of Errors in Dictated Clinical Documents Assisted by Speech Recognition Software and Professional Transcriptionists | JAMA Network Open | JAMA Network
How accurate are dictated clinical documents created by speech recognition software, edited by professional medical transcriptionists, and reviewed and signed by physicians?
digital-health  voice-recognition 
july 2018
Robin Healthcare comes out of stealth mode with AI tool for clinical documentation - MedCity News
The startup's tool sits in the exam room, and the doctor talks to the patient throughout the appointment. Afterward, the notes are sitting in the EMR waiting for the physician to review and sign.
digital-health  voice-recognition 
july 2018
New Content Collection in JCO Clinical Cancer Informatics Examines the Field of Digital Health—Where it is now and Where it’s Leading | ASCO
On June 29, JCO Clinical Cancer Informatics (JCO CCI) published its second special collection of articles. This collection highlights new areas of digital health, providing a broad overview of the current state of technology in cancer care, as well as where the field may be headed in the future.
digital-health  ASCO-review 
july 2018
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