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Quercki : vitamind   9

Is Sunscreen the New Margarine? | Outside Online
Sunny Australia changed its tune back in 2005. Cancer Council Australia’s official-position paper (endorsed by the Australasian College of Dermatologists) states, “Ultraviolet radiation from the sun has both beneficial and harmful effects on human health.... A balance is required between excessive sun exposure which increases the risk of skin cancer and enough sun exposure to maintain adequate vitamin D levels.... It should be noted that the benefits of sun exposure may extend beyond the production of vitamin D. Other possible beneficial effects of sun exposure… include reduction in blood pressure, suppression of autoimmune disease, and improvements in mood.”
sun  VitaminD  hypertension  depression  cancer 
10 weeks ago by Quercki
Causal link found between vitamin D, serotonin synthesis and autism in new study -- ScienceDaily
February 26, 2014
Children's Hospital & Research Center Oakland
Serotonin and vitamin D have been proposed to play a role in autism, however, no causal mechanism has been established. Now, researchers show that serotonin, oxytocin, and vasopressin, three brain hormones that affect social behavior related to autism, are all activated by vitamin D hormone. Supplementation with vitamin D and tryptophan would be a practical and affordable solution to help prevent autism and possibly ameliorate some symptoms of the disorder.
VitaminD  autism 
march 2014 by Quercki
PLoS ONE: A Prospective Randomized Controlled Trial of the Effects of Vitamin D Supplementation on Cardiovascular Disease Risk
Effects of Treatment with VitD or Placebo

After 4 months, serum 25(OH)D increased by 15.7 (9.3) ng/mL in the treatment group versus −0.2 (6.1) ng/mL in those taking placebo (p<0.001). Despite improved VitD status, there were no significant differences between groups in any of the pre-specified outcomes including change in absolute FMD (0.001 [0.009] vs. 0.001 [0.013] cm p = 0.729), maximum relative FMD (0.3 [3.4] vs. 0.3 [2.6] %, p = 0.77), PWV (0.00 [1.06] vs. 0.05 [0.92] m/s, p = 0.65), AIx (2.7 [6.3] vs. 0.9 [5.6] %, p = 0.10), or CRP (0.3 [1.9] vs. 0.3 [4.2] mg/L, p = 0.97) (Table 2, Figure 2). Additionally, there were no significant changes in central aortic or brachial blood pressures (p>0.4). There was a small, statistically significant increase in the total/high-density lipoprotein cholesterol ratio in the placebo group compared to the treatment group (0.17 [0.36] vs. 0.07 [0.39], p<0.001). No adverse events were reported.

Of those in the treatment group, 92% (N = 51) had vitamin D levels >30 ng/mL after 4 months of therapy. General linear models showed no significant interaction between treatment group and VitD status for changes in maximum relative FMD (p = 0.65), PWV (p = 0.93), AIx (p = 0.97), or CRP (p = 0.26). No differences were observed after adjustment for baseline body-mass index.
august 2012 by Quercki
Vitamin D status of seminomadic Fulani men ... [J Natl Med Assoc. 2010] - PubMed - NCBI
The purpose of this study was to assess the vitamin D status of Fulani men and women in northern Nigeria. The Fulani are seminomadic pastoralists whose culture, economy, and diet are centered on cattle. Most of the foods consumed by the Fulani are not good sources of vitamin D. Also being Muslim, the women do not derive much benefit from the vitamin D-generating effects of sunlight due to their dress habits. Furthermore, childhood rickets is common in the region. Serum was collected from 22 Fulani men (age, 47.6 +/- 8.3 years; body mass index [BMI], 21.1 +/- 3.2 kg/m2) and 29 women (age, 55.5 +/- 13.5 years; BMI, 21.6 +/- 3.1 kg/m2) in rural northern Nigeria and analyzed for 25-hydroxyvitamin D2 and D3 using ultraperformance liquid chromatography coupled with mass spectrometry Eighty-three percent of the women and 45% of the men had serum 25-hydroxyvitamin D levels in the hypovitaminosis D range (10-30 ng/mL). In the males, there was a strong negative correlation between serum vitamin D and BMI (r = -0.49, p = .022) and percent body fat (r = -0.51, p = .015). No such correlations were observed in the Fulani women. Our main conclusion is that about half the men and most of the women in the Fulani community where this study was conducted are inadequately nourished with respect to vitamin D. A high prevalence of hypovitaminosis D indicates an elevated risk for rickets in children and bone fractures in adults.
VitaminD  muslim  sunlight  women 
july 2012 by Quercki
Vitamin D and Prevention of Cancer — Ready for Prime Time? — NEJM
The committee's comprehensive review of the evidence regarding vitamin D's role in preventing cancer, however, revealed that the research is inconsistent and doesn't establish a cause–effect relationship. Other recent reviews have reached similar conclusions.2,3 No large-scale randomized clinical trial of vitamin D has been completed with cancer as the primary prespecified outcome. Most evidence is derived from laboratory studies, ecologic correlations, and observational investigations of serum 25-hydroxyvitamin D levels in association with cancer outcomes. Although this serum measure is a useful marker of current vitamin D exposure, associational studies have important limitations. Specifically, low serum 25-hydroxyvitamin D levels are also linked with confounding factors related to higher cancer risk, including obesity (vitamin D becomes sequestered in adipose tissue), lack of physical activity (correlated with less time outdoors and less solar exposure), dark skin pigmentation (less skin synthesis of vitamin D in response to sun), and diet or supplementation practices. Reverse-causation bias may also occur if poor health reduces participation in outdoor activities and sun exposure or adversely affects diet, resulting in lower vitamin D levels. Association therefore cannot prove causation. Many micronutrients that seemed promising in observational studies (e.g., beta carotene, vitamins C and E, folic acid, and selenium) were not found to reduce cancer risk in randomized clinical trials, and some were found to cause harm at high doses.4
VitaminD  cancer  diet 
march 2011 by Quercki
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol -- Heaney et al. 77 (1): 204 -- American Journal of Clinical Nutrition
Key Words: Vitamin D • cholecalciferol • 25-hydroxycholecalciferol • nutrient requirement • parathyroid hormone • seasonal variation • tolerable upper input level
march 2009 by Quercki

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