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aries1988 : cancer   8

Cancer’s Invasion Equation | The New Yorker
Rather than viewing invasiveness as a quality intrinsic to a cancer, researchers needed to consider invasiveness as a pathological relationship between an organism and an environment. “Together, cancer cells and host cells form an ecosystem,” Pienta reminded the audience. “Initially, the cancer cells are an invasive species to a new niche or environment. Eventually, the cancer-cell-host-cell interactions create a new environment.” Ask not just what the cancer is doing to you, Pienta was saying. Ask what you are doing to the cancer.

There are important consequences of taking soil as well as seed into account. Among the most successful recent innovations in cancer therapeutics is immunotherapy, in which a patient’s own immune system is activated to target cancer cells.

This is medicine’s “denominator problem.” The numerator is you—the person who gets ill. The denominator is everyone at risk, including all the other passengers who were exposed. Numerators are easy to study. Denominators are hard. Numerators come to the doctor’s office, congested and miserable. They get blood tests and prescriptions. Denominators go home from the subway station, heat up dinner, and watch “The Strain.” The numerator persists. The denominator vanishes.

We err toward risk aversion, even at the cost of bodily damage; we don’t learn what would happen if we did nothing. It was a classic “denominator” problem, but my response seemed supremely unsatisfactory.

Perhaps we all gave up. Considering the limitations of our knowledge, methods, and resources, our field may have had no choice but to submit to the lacerations of Occam’s razor, at least for a while. It was only natural that many cancer biologists, confronting the sheer complexity of the whole organism, trained their attention exclusively on our “pathogen”: the cancer cell.

we physicians have been drawn to the toggle-switch model of disease and health: the biopsy was positive; the blood test was negative; the scans find “no evidence of disease.” Good germs, bad germs. Ecologists, meanwhile, talk about webs of nutrition, predation, climate, topography, all subject to complex feedback loops, all context-dependent. To them, invasion is an equation, even a set of simultaneous equations.

the true meaning of “holistic”: to take the body, the organism, its anatomy, its physiology—this infuriatingly intricate web—as a whole
cancer  medicine  health  research 
july 2018 by aries1988
在 D 版发过了,不过因为不少朋友看不到 D 版,我就放在这里吧,说说我最近做的这个 Project - V2EX
分享创造 - @coolwulf - 去年的时候,我一个在芝加哥比我小几级的南京大学校友去世了。乳腺癌,发现得晚了,才 34 岁,留下了一个 4 岁的孩子。非常可惜。想想能不能做点什么事情可以帮助大众来提高乳腺癌的早期检测成功率。因为如果
ai  health  online  cancer  tool 
june 2018 by aries1988
Medicine’s Burning Question
“Inflammation is the final common pathway for pretty much all chronic diseases,” he told me. His recommended solution is an “anti-inflammatory diet”—omitting sugar, caffeine, beans, dairy, gluten, and processed foods, as well as taking a variety of supplements, including probiotics, fish oil, Vitamins C and D, and curcumin, a key molecule in turmeric.
question  medicine  research  theory  body  cancer 
december 2017 by aries1988
There’s a big problem with AI: even its creators can’t explain how it works

In 2015, researchers at Google modified a deep-learning-based image recognition algorithm so that instead of spotting objects in photos, it would generate or modify them. By effectively running the algorithm in reverse, they could discover the features the program uses to recognize, say, a bird or building. The resulting images, produced by a project known as Deep Dream, showed grotesque, alien-like animals emerging from clouds and plants, and hallucinatory pagodas blooming across forests and mountain ranges.
ai  health  medical  cancer  problem  communication  today  human  google  art  visualization  algorithm 
april 2017 by aries1988
小公务员之死
我姐夫临终以前跟我说让我给他写挽联,他说你字好。我这个人一辈子就好一个穷讲究,说完他看着天花板微笑着。
cancer  death  family  story  instapaper_favs 
may 2016 by aries1988

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