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charlesarthur : ebola   5

Ebola now curable after trials of drugs in DRC, say scientists • The Guardian
Sarah Boseley:
<p>Ebola can no longer be called an incurable disease, scientists have said, after two of four drugs being trialled in the major outbreak in the Democratic Republic of the Congo were found to have significantly reduced the death rate.

ZMapp, used during the massive Ebola epidemic in Sierra Leone, Liberia and Guinea, has been dropped along with Remdesivir after two monoclonal antibodies, which block the virus, had substantially more effect, said the World Health Organization and the US National Institute of Allergy and Infectious Diseases, which was a co-sponsor of the trial.

The trial in the DRC, which started in November, has now been stopped. All Ebola treatment units will now use the two monoclonal antibody drugs.

“From now on, we will no longer say that Ebola is incurable,” said Prof Jean-Jacques Muyembe, the director general of the Institut National de Recherche Biomédicale in DRC, which has overseen the trial. “These advances will help save thousands of lives.”</p>
ebola  virus 
9 weeks ago by charlesarthur
Is Ebola evolving into a more deadly virus? • The New Yorker
Richard Preston:
<p>This July, the World Health Organization declared that an outbreak of Ebola in the provinces of Ituri and North-Kivu, in the eastern Democratic Republic of the Congo, was a “public health emergency of international concern.” This particular strain of the virus, which first appeared in the region in 2018 and hasn’t been given a formal name—I’ll call it Kivu Ebola—is a variant of a species known as the Zaire Ebola virus. As of last Saturday, 2,753 cases of Kivu Ebola have been reported, with 1,843 deaths. There appear to be many undiscovered cases in the region, too. Ella Watson-Stryker, a social scientist with Doctors Without Borders, who has been studying the outbreak, said that around half of all Ebola patients admitted to treatment centers in eastern Congo aren’t part of any known chain of transmission. In other words, the infected person has caught Ebola from somebody whom disease investigators haven’t yet identified. “A lot of transmission is not being seen, but nobody knows the exact amount,” Watson-Stryker told me…

…The Kivu Ebola outbreak area is in a conflict zone, beset by armed militias and ethnic violence. Local people often don’t trust the international medical organizations that run the Ebola treatment centers. There have been at least 194 attacks on local health workers, seven of whom have been killed. Watson-Stryker, the researcher, said that social media complicates containment and treatment efforts. Conspiracy theories about medical workers and false information about how the virus is spread are ricocheting around popular platforms like WhatsApp. “The problem is the post-factual reality that exists in social media,” she said…

…The Kivu Ebola, so far, has mutated into four lineages. Three of the four are active in the population. The swarm is exploring people’s immune systems and jumping from one victim to the next. So far, none of the three active varieties has become dominant. “The virus has been brewing in that area for a while,” [Pardis] Sabeti [a genomic scientist] said. “If you give Ebola enough time to transmit from human to human, then an unpredictable event can occur. How likely is it that Ebola could change suddenly? We don’t have a good answer to that question.”</p>


Preston wrote "The Hot Zone", and has been reporting on Ebola since 1992. If you're wondering.
ebola  mutation 
10 weeks ago by charlesarthur
Measles is killing more people in the DRC than Ebola—and faster • Ars Technica
Beth Mole:
<p>Since January 2019, officials have recorded over 100,000 measles cases in the Democratic Republic of Congo, mostly in children, and nearly 2,000 have died. The figures surpass those of the latest Ebola outbreak in the country, which has tallied not quite 2,500 cases and 1,665 deaths since August 2018. The totals were noted by World Health Organization Director-General, Tedros Adhanom Ghebreyesus, in a speech today, July 15, at the United Nations Office in Geneva, Switzerland.

"Frankly, I am embarrassed to talk only about Ebola," Dr. Tedros said (he goes by his first name). He gave the speech in response to two new developments in the Ebola outbreak. That is that two Ebola responders were murdered in their home in the DRC city of Beni and that officials on Sunday had identified the first case of Ebola in Goma, a DRC city of over one million at the border with Rwanda.</p>


In case there's anyone around who thought measles wasn't deadly.
ebola  measles 
july 2019 by charlesarthur
Massive Ebola outbreak spreads across DRC border, infected five-year-old in Uganda • Ars Technica
Beth Mole:
<p>Health officials in Uganda have confirmed the country’s first case of Ebola stemming from <a href="https://arstechnica.com/science/2019/03/ebola-cases-surpass-1000-in-drc-outbreak-the-second-largest-of-all-time/">a massive outbreak that has been raging across the border</a> in the Democratic Republic of the Congo since August of 2018.

The World Health Organization reported Tuesday, June 11, that the case is in a five-year-old boy from the DRC who traveled with his family into Uganda on June 9. The boy’s case was confirmed by the Uganda Virus Institute (UVRI), and he’s receiving care in the Ebola Treatment Unit in the western Ugandan town of Bwera, which sits at the border with DRC.

Health officials have feared the spread of the virus, which has festered in DRC’s North Kivu and Ituri provinces for nearly a year. The provinces sit on the eastern side of the country, bordering South Sudan, Uganda, and Rwanda. As of June 9, the WHO reports 2,062 cases (1,968 confirmed and 94 probable), including 1,390 deaths (1,296 confirmed and 94 probable) in the outbreak. It is the second largest Ebola outbreak on record, surpassed only by the 2014 West African outbreak, which involved more than 28,000 cases and 11,000 deaths.</p>


Current existential risks to civilisation: climate emergency, asteroid strike, nuclear confrontation/accident.. and pandemic. Quite a lot of scientists worry about the latter one because it would only have to affect a tiny percentage of the population to have a dramatic effect on social order.
ebola 
june 2019 by charlesarthur
Fighting Ebola is hard. In Congo, fake news makes it harder • AAAS
Laura Spinney:
<p>The Ebola epidemic in the Democratic Republic of the Congo (DRC) is providing a natural experiment in fighting fake news. Occurring in a conflict zone, amid a controversial presidential election, the epidemic has proved to be fertile ground for conspiracy theories and political manipulation, which can hamper efforts to treat patients and fight the virus’s spread. Public health workers have mounted an unprecedented effort to counter misinformation, saying the success or failure of the Ebola response may pivot on who controls the narrative.

Tensions are expected to rise again in the wake of the 10 January declaration by the DRC’s election commission that opposition leader Felix Tshisekedi won the election, held on 30 December 2018. Foreign observers and the Roman Catholic Church’s monitors say Martin Fayulu, another opposition figure, garnered more votes, and his supporters are alleging fraud. Health workers know rumors thrive amid uncertainty.

“I usually tell my teams that we fight two outbreaks, Ebola and fear,” says Carlos Navarro Colorado of the United Nations International Children’s Emergency Fund (UNICEF) in New York City. “It is all about information.”</p>


Now that would be a truly scary thing to have to deal with.
ebola  fakenews 
april 2019 by charlesarthur

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