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tsuomela : immunology   5

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"According to the ‘hygiene hypothesis’, the decreasing incidence of infections in western countries and more recently in developing countries is at the origin of the increasing incidence of both autoimmune and allergic diseases. The hygiene hypothesis is based upon epidemiological data, particularly migration studies, showing that subjects migrating from a low-incidence to a high-incidence country acquire the immune disorders with a high incidence at the first generation. However, these data and others showing a correlation between high disease incidence and high socio-economic level do not prove a causal link between infections and immune disorders. Proof of principle of the hygiene hypothesis is brought by animal models and to a lesser degree by intervention trials in humans. Underlying mechanisms are multiple and complex. They include decreased consumption of homeostatic factors and immunoregulation, involving various regulatory T cell subsets and Toll-like receptor stimulation. These mechanisms could originate, to some extent, from changes in microbiota caused by changes in lifestyle, particularly in inflammatory bowel diseases. Taken together, these data open new therapeutic perspectives in the prevention of autoimmune and allergic diseases."
health  medicine  allergies  immunology  diseases 
september 2013 by tsuomela
WHO | Antimicrobial resistance: revisiting the “tragedy of the commons”
Q: Is this the doomsday scenario of a world without antibiotics?

A: Unfortunately yes, with these new multiresistant NDM1-containing strains and their potential for worldwide spread. Doctors will face a terrible dilemma when a pregnant woman develops a kidney infection that spills over into the bloodstream with a pan-resistant strain containing NDM1 and there are no treatment options. We are essentially back to an era with no antibiotics...
Q: What can World Health Day 2011 achieve in terms of containing antimicrobial resistance?

A: A focus such as this is an unparalleled opportunity for WHO to step to the fore and to bring together its personnel working in this area – those working on rational drug use, surveillance networks, laboratories, the World Health Day team, the infection prevention and control team and others – to create a cross-organizational taskforce to update and rejuvenate the excellent work produced a decade ago...
health  immunization  immunology  antibiotics  environment  medicine  future  gloom-and-doom 
november 2010 by tsuomela

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