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What are the Laws of Biology?
The core finding of systems biology is that only a very small subset of possible network motifs is actually used and that these motifs recur in all kinds of different systems, from transcriptional to biochemical to neural networks. This is because only those arrangements of interactions effectively perform some useful operation, which underlies some necessary function at a cellular or organismal level. There are different arrangements for input summation, input comparison, integration over time, high-pass or low-pass filtering, negative auto-regulation, coincidence detection, periodic oscillation, bistability, rapid onset response, rapid offset response, turning a graded signal into a sharp pulse or boundary, and so on, and so on.

These are all familiar concepts and designs in engineering and computing, with well-known properties. In living organisms there is one other general property that the designs must satisfy: robustness. They have to work with noisy components, at a scale that’s highly susceptible to thermal noise and environmental perturbations. Of the subset of designs that perform some operation, only a much smaller subset will do it robustly enough to be useful in a living organism. That is, they can still perform their particular functions in the face of noisy or fluctuating inputs or variation in the number of components constituting the elements of the network itself.
scitariat  reflection  proposal  ideas  thinking  conceptual-vocab  lens  bio  complex-systems  selection  evolution  flux-stasis  network-structure  structure  composition-decomposition  IEEE  robust  signal-noise  perturbation  interdisciplinary  graphs  circuits  🌞  big-picture  hi-order-bits  nibble  synthesis 
3 days ago by nhaliday
How to Structure Your Rap Song
Structure is the thread that holds your rap song together, as it connects every part of the song and keeps things organized.
rap  song  songwriting  structure 
5 days ago by Adventure_Web

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